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A foundational human study on this receptor pairing found that GHRP and GHRH synergistically stimulate GH release, suggesting that GHRP and GHRH act independently through separate physiological systems

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However, it should be noted that current evidence regarding amino acid metabolism-mediated regulation of macrophage polarization is derived mainly from in vitro macrophage models and animal experiments, whereas systematic validation in human diseases remains relatively limited

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