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[1] Toxicity is extremely rare, though adverse reactions including hypersensitivity can occur, particularly with injectable forms

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In the UK, healthcare professionals are advised to check and monitor serum vitamin B12 levels in patients treated with metformin and who have symptoms suggestive of vitamin B12 defi­ciency ( levels-new-advice-for-monitoring-patients-at-risk)

Vitamin B12 helps your body use fat and carbohydrates for energy and make new protein