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Animal and tissue Adult male SD rats, weight 250–300 g were purchased from National Laboratory Animal Center (Taipei, Taiwan, ROC)

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9 Additionally, although an intensive lifestyle intervention for WL in the Look AHEAD: Action for Health in Diabetes (LookAHEAD) trial did not show reduction in major adverse cardiovascular events (MACE-4) in people with T2DM and obesity compared to a diabetes education and support program, a post hoc analysis demonstrated that those who lost ≥10% of their baseline body weight during the first year of the trial had a 21% lower risk for cardiovascular events over a 10 years follow-up period compared to those with stable weight or weight gain