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Although serum glutamine is not significantly altered between healthy controls and patients with steatohepatitis, serum glutamate, a metabolite which metabolic pathways are closely related to glutamine, is augmented in patients with steatohepatitis ( Hepatic glutamine metabolism is mostly regulated by the actions of the glutaminase enzyme ( GLS2 expression, the liver type glutaminase, is decreased in steatohepatitis ( Figure 1B )
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