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The triterpenoid class of Nrf2 activators has been shown to be much more potent at activating Nrf2 and ARE than naturally derived compounds [60]

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Melatonin enhances antioxidative enzyme gene expression (CAT, GPx, SOD), prevents their UVR-induced depletion, and protects against the formation of DNA damage (8-hydroxy-2′-deoxyguanosine) in ex vivo human skin