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It is found that stroke can trigger the release of central and peripheral galactin-3 causing enteric neuronal loss through by regulating the transforming growth factor β-activated kinase 1 (TAK1) or AMP activated kinase (AMPK) ( Paenalcaligenes and Escherichia coli can penetrate the brain through the blood and vagus nerve, leading to cognitive impairment (Lee et al., 2020)